India has the highest prevalence of IDA worldwide, which has been estimated to affect 70% of children, 55% of women of reproductive age, and 85% of pregnant women ( 5). Iron deficiency is the leading cause of anemia, with women of reproductive age being particularly vulnerable to acquiring iron-deficiency anemia (IDA) 8 because of the increase in blood volume and muscle mass that occurs around puberty followed by regular menstruation, which increases the body’s demand for iron ( 3, 4). Iron deficiency is the most common nutritional disorder in the world, with the highest prevalence in children (40%), women of reproductive age (30%), and pregnant women (38%) ( 1, 2). Hematocrit, hemoglobin, Indian diet, iron-deficiency anemia, iron-supplement bar, Let’s be Well Red, women INTRODUCTION This trial was registered at as NCT02032615. This intervention is an attractive option to combat anemia in India. ![]() The anemia prevalence at 90 d was lower for intervention (29.2%) than for control participants (98.6%) (OR: 0.007 95% CI: 0.001, 0.04).Ĭonclusions: The daily consumption of an iron-supplement bar leads to increased hemoglobin concentrations and hematocrit percentages and to a lower anemia prevalence in the target population with no reported side effects. Mean hemoglobin and hematocrit increases after 90 d were greater for intervention than for control participants. ![]() Baseline characteristics were comparable by arm. Results: Of 179 anemic participants, 136 (76.0%) completed all follow-up assessments (65 intervention and 71 control participants). Linear mixed models and generalized estimating equations were used to model continuous and binary outcomes, respectively. Primary outcomes were 90-d changes from baseline in hemoglobin concentrations and hematocrit percentages. CBC tests were given at days 15, 45, and 90. Intervention participants received 1 iron-supplement bar (containing 14 mg Fe)/d for 90 d, whereas control subjects received nothing. Random assignment of anemic participants to intervention and control arms occurred within 5 matched site-pairs. ![]() All participants received anemia education and a complete blood count (CBC). A total of 361 nonpregnant women (age 18–35 y) were recruited from 10 sites within Mumbai and Navi Mumbai, India. Objective: We assessed the efficacy of the consumption of iron-supplement bars in raising hemoglobin concentrations and hematocrit percentages in anemic (hemoglobin concentration <12 g/dL) Indian women of reproductive age.ĭesign: The Let’s be Well Red study was a 90-d, pair-matched, cluster-randomized controlled trial. Background: India’s high prevalence of iron-deficiency anemia has largely been attributed to the local diet consisting of nonheme iron, which has lower absorption than that of heme iron.
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